NIPBL Antibody

The NIPBL (Nipped B-like) gene was originally identified as a gene mutated in individuals with Cornelia de Lange syndrome (CdLS), a heterogenous developmental disorder associated with multiple anatomical malformations. The NIPBL protein product is also referred to as delangin. It has substantial homology to the D. melanogaster Nipped-B protein which is related to a family of chromosomal adherins that plays a role in sister chromatid adhesion, chromosome condensation, and DNA repair. A study of metaphase spreads from individuals positive and negative for NIPBL mutations revealed an association between NIPBL mutations and precocious sister chromatid separation. This result suggests a function for NIPBL that is similar to its homolog in drosophila.
NIPBL
NIPBL, cohesin loading factor
Nipped-B-like protein
:  CDLS CDLS1 delangin DKFZp434L1319 FLJ11203 FLJ12597 FLJ13354 FLJ13648 IDN3 IDN3-B Nipped-B homolog Scc2 SCC2 homolog sister chromatid cohesion 2 homolog sister chromatid cohesion 2 homolog (yeast)
Product
Specifications
Ordering Information
Human
IP
Between 550 and 600
100
$339
$99
Human
WB, IP
Between 1025 and 1075
100
$339
$229
$99
Human
100
Includes: 1 each of A301-778A and A301-779A
$472
Includes: 1 each of A301-778A and A301-779A