Rabbit anti-NIPBL Antibody Affinity Purified
Catalog #
NIPBL
Human
IP
Rabbit
Polyclonal
Whole IgG
between 550 and 600
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
The NIPBL (Nipped B-like) gene was originally identified as a gene mutated in individuals with Cornelia de Lange syndrome (CdLS), a heterogenous developmental disorder associated with multiple anatomical malformations. The NIPBL protein product is also referred to as delangin. It has substantial homology to the D. melanogaster Nipped-B protein which is related to a family of chromosomal adherins that plays a role in sister chromatid adhesion, chromosome condensation, and DNA repair. A study of metaphase spreads from individuals positive and negative for NIPBL mutations revealed an association between NIPBL mutations and precocious sister chromatid separation. This result suggests a function for NIPBL that is similar to its homolog in drosophila.
Alternate Names
CDLS; CDLS1; delangin; IDN3; IDN3-B; Nipped-B homolog; nipped-B-like protein; Scc2; SCC2 homolog; sister chromatid cohesion 2 homolog
Applications