It’s Saturday night and you’re getting a few drinks with friends. Someone suggests shots, and afterward you notice that one of your friends is bright red. “Did you get sunburnt today?” you ask.
“It’s Asian glow!” she says, “I’m Taiwanese, so I don’t have the gene that breaks down alcohol.”
Protein and nucleic acid interactions are vital to cellular processes. Proteins associate with nucleic acids to mediate transcription and translation of DNA and RNA to decode the information carried by genetic material. In addition, protein–nucleic acid interactions are required to maintain the integrity of DNA and RNA throughout generations. To do so, proteins interact with nucleic acids in processes such as DNA replication, repair and processing, as well as RNA processing and translocation.
Ras-related nuclear protein (Ran), a member of the Ras superfamily of small GTPases, plays a critical role in the transport of macromolecules between the nucleus and the cytoplasm that occurs through nuclear pores. More recently, research has shown that Ran participates in the coordination of mitosis, with specific roles in mitotic spindle assembly, centrosome duplication, microtubule dynamics, and chromosome alignment.1
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