/ ANTIBODIES/ANTISERA / Primary Antibodies / Rabbit anti-TIM3 Recombinant Monoclonal Antibody [BLR207K]
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Primary Antibodies  

Rabbit anti-TIM3 Recombinant Monoclonal Antibody [BLR207K]

bethyl
Bethyl Laboratories

Catalog #

Validated
Target:

TIM3

Reactivity:

Mouse

Applications:

IP

,

WB

Host:

Rabbit

Clonality:

Recombinant Monoclonal

Clone:

BLR207K

Format:

Whole IgG

Immunogen:

between 231 and 281 (C-term)

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Purified

100 µl (10 blots)

20 µl (2 blots)

100 µg (BSA-Free)

Product Details

Specifications
Verified Reactivity

Mouse

Antigen Species

Human

Concentration
100 µg/ml 1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide


Request Formulation Change

Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free


Request Formulation Change
Additional Product Information

TIM3 (HAVCR2) is a cell surface receptor implicated in modulating innate and adaptive immune responses. It is generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. TIM3 regulates macrophage activation, inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses, and promotes immunological tolerance. In CD8+ cells TIM3 attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TDQ0].

171285

Havcr2

hepatitis A virus cellular receptor 2

Q8VIM0

Hepatitis A virus cellular receptor 2 homolog

Alternate Names

CD antigen CD366; HAVcr-2; hepatitis A virus cellular receptor 2 homolog; T-cell immunoglobulin and mucin domain containing 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; TIM-3; Timd3; TIMD-3

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.