Rabbit anti-TAB182 Antibody Affinity Purified
Catalog #
TAB182
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 225 and 275
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to TAB182 immobilized on solid support.
The epitope recognized by A301-437A maps to a region between residue 200 and 250 of human tankyrase 1-binding protein of 182 kDa using the numbering given in entry NP_203754.2 (GeneID 85456).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to TAB182 immobilized on solid support.
The epitope recognized by A301-437A-T maps to a region between residue 200 and 250 of human tankyrase 1-binding protein of 182 kDa using the numbering given in entry NP_203754.2 (GeneID 85456).
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.
Alternate Names
182 kDa tankyrase-1-binding protein; TAB182; tankyrase 1 binding protein 1, 182kDa; tankyrase 1-binding protein of 182 kDa; testis secretory sperm-binding protein Li 206a
Applications