Rabbit anti-Rad9 IHC Antibody Affinity Purified
Catalog #
Rad9
Human
IHC
,IHC-IF
Rabbit
Polyclonal
Whole IgG
Between 350 and C-term
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Dog,
Pig,
Bovine,
Monkey
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to Rad9 immobilized on solid support.
The epitope recognized by IHC-00376 maps to a region between residue 350 and the C-terminus (residue 391) of human Rad9 using the numbering given in entry NP_004575.1 (GeneID 5883).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to Rad9 immobilized on solid support.
The epitope recognized by IHC-00376-T maps to a region between residue 350 and the C-terminus (residue 391) of human Rad9 using the numbering given in entry NP_004575.1 (GeneID 5883).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Rad9 is a cell-cycle checkpoint protein with 3’-5’ exonuclease activity and is part of the 9-1-1 complex. The 9-1-1 complex, also called the checkpoint clamp, is a trimeric complex that includes Rad9, Hus1, and Rad1. This complex is recruited by the RAD17/RFC clamp loader to DNA lesions where it aids in the activation of Chk2 by ATM and ATRIP and the subsequent triggering of the checkpoint signaling cascade. In addition to its role in sensing DNA damage, Rad9 also functions in the base excision repair process of DNA repair.
Alternate Names
cell cycle checkpoint control protein RAD9A; DNA repair exonuclease rad9 homolog A; hRAD9; RAD9; RAD9 homolog A
Applications