Rabbit anti-PTPN11/Shp2 Antibody Affinity Purified
Catalog #
PTPN11/Shp2
Human
,Mouse
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 543 and 593
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Chicken
Human
2 - 8 °C
1 year from date of receipt
PTPN11/Shp2 is a src-homology 2-containing protein-tyrosine phosphatase (PTP). PTPN11/Shp2 is a non-receptor phosphatase that mediates a variety of cytokine, growth factor, and hormone signals. Signal transduction by PTPN11/Shp2 is achieved via the activation of the Ras/mitogen-activated protein kinase pathway. Heterogenous gain of function mutations in PTPN11/Shp2 are associated with juvenile myelomonocytic leukemia (JMML) and Noonan syndrome, a disorder characterized by short stature, facial dysmorphology, and congenital heart defects.
Tyrosine-protein phosphatase non-receptor type 11
Alternate Names
BPTP3; CFC; JMML; METCDS; NS1; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase 2C; PTP-1D; PTP2C; PTP-2C; SHP2; SHP-2; SH-PTP2; SH-PTP3; tyrosine-protein phosphatase non-receptor type 11
Applications