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Primary Antibodies  

Rabbit anti-PITRM1 Antibody

Bethyl Laboratories®
Bethyl Laboratories®

Catalog #

Validated
Target:

PITRM1

Reactivity:

Human

Applications:

IP

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

Between 987 and 1037

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

Product Details

Specifications
Verified Reactivity

Human

Antigen Species

Human

Concentration
1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide


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Additional Product Information

Pitrilysin metalloproteinase 1 (PITRM1) is an ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. PITRM1 also degrades other unstructured peptides. It is specific for peptides in the range of 10 to 65 residues. It is able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. PTMRM shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5JRX3].

10531

PITRM1

pitrilysin metallopeptidase 1

Q5JRX3

Presequence protease, mitochondrial

Alternate Names

hMP1; hPreP; Metalloprotease 1; metalloprotease 1 (pitrilysin family); MP1; pitrilysin metalloproteinase 1; PreP; PreP peptidasome; presequence protease, mitochondrial

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.