Rabbit anti-NF2 IHC Antibody Affinity Purified
Catalog #
NF2
Human
IHC
,IHC-IF
Rabbit
Polyclonal
Whole IgG
Between 550 and C-term
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Horse,
Dog,
Pig,
Rabbit,
Bovine,
Rat
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to NF2 isoform1 immobilized on solid support.
The epitope recognized by IHC-00193 maps to a region between residues 550 and the C-terminus (residue 595) of human Neurofibromin 2 using the numbering given in entry NP_000259.1 (GeneID 4771). This epitope is common to NF2 isoforms 1 and 9 (Mer162).
Antibody was affinity purified using an epitope specific to NF2 isoform1 immobilized on solid support.
The epitope recognized by IHC-00193-T maps to a region between residues 550 and the C-terminus (residue 595) of human Neurofibromin 2 using the numbering given in entry NP_000259.1 (GeneID 4771). This epitope is common to NF2 isoforms 1 and 9 (Mer162).
Mutations in NF2 (neurofibromin 2) are associated with neurofibromatosis type II which is characterized by Schwann cell tumors (schwannomas) which are benign slow-growing tumors that are resistant to chemotherapeutic intervention. NF2 is a membrane/cytoskeletal associated protein that has been classified as a novel type of tumor suppressor due to its function in membrane organization versus a classic tumor suppressor function that regulates cell cycle machinery.
Alternate Names
ACN; BANF; merlin; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma); Neurofibromin-2; SCH; schwannomerlin; schwannomin
Applications