Rabbit anti-Menin IHC Antibody
Catalog #
Menin
Human
,Mouse
IHC
Rabbit
Polyclonal
Whole IgG
Between 575 and C-term
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Guinea_pig,
Horse,
Dog,
Pig,
Bovine,
Monkey,
Rat
Human
2 - 8 °C
1 year from date of receipt
Menin is the gene product of the putative tumor suppressor MEN1 associated with the syndrome termed multiple endocrine neoplasia type 1 that may function in the regulation of DNA synthesis or the response to DNA damage. Menin has been shown to interact with JunD, a member of the AP-1 heterodimer and inhibit transcription. Menin has also been shown to interact with Pem, FANCD2, RPA, NMMHCII-A, GFAP, vimentin, Hsp70, NfkappaB proteins, Smads, mSin3A and is part of the MLL2 and MLL1 Set1-like histone H3 K4 methyltransferase complex where it interacts directly with ASH2, Rbbp5, and WDR5. As part of the MLL complexes, menin may mediate its tumor suppressor activity via the regulation of histone methylation of HOX and CDK inhibitor genes. Alternative names for Menin are MEAI, multiple endocrine adenomatosis 1, suppressor Candidate Gene 2, and SCG2.
Alternate Names
MEAI; menin; SCG2
Applications
