Rabbit anti-JMY IHC Antibody Affinity Purified
Catalog #
JMY
Human
IHC
Rabbit
Polyclonal
Whole IgG
Between 1 and 50
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Guinea Pig,
Mouse,
Dog,
Bovine,
Monkey
Human
2 - 8 °C
1 year from date of receipt
Junction-mediating and -regulatory protein (JMY) acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In the nucleus, JMY acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300 and increases p53/TP53-dependent transcription and apoptosis suggesting an important role in p53/TP53 stress response such as DNA damage. In the cytoplasm, JMY acts as a nucleation-promoting factor for both branched and un-branched actin filaments. It activates the Arp2/3 complex to induce branched actin filament networks and also catalyzes actin polymerization in the absence of Arp2/3, creating un-branched filaments [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N9B5].
Junction-mediating and -regulatory protein
Alternate Names
junction-mediating and -regulatory protein; WAS protein homology region 2 domain containing 1-like 3; WHAMM2; WHDC1L3
Applications
