Rabbit anti-CNOT1 Antibody
Catalog #
CNOT1
Human
,Mouse
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 1400 and 1450
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
X_tropicalis,
Zebrafish
Human
2 - 8 °C
1 year from date of receipt
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. [taken from NCBI Entrez Gene (Gene ID: 23019)]. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/A5YKK6].
CCR4-NOT transcription complex subunit 1
Alternate Names
AD-005; adrenal gland protein AD-005; CCR4-associated factor 1; CCR4-NOT transcription complex subunit 1; CDC39; hNOT1; negative regulator of transcription subunit 1 homolog; NOT1; NOT1 (negative regulator of transcription 1, yeast) homolog; NOT1H
Applications