Rabbit anti-BRCC36 IHC Antibody Affinity Purified
Catalog #
BRCC36
Human
IHC
Rabbit
Polyclonal
Whole IgG
Between 266 and 316
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Horse,
Pig,
Monkey
Human
2 - 8 °C
1 year from date of receipt
BRCA1/BRCA2-containing complex subunit 36 (BRCC36) is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. BRCC36 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, BRCC36 specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P46736].
Alternate Names
BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRCA1-A complex subunit BRCC36; BRCC36; BRISC complex subunit BRCC36; C6.1A; CXorf53; lys-63-specific deubiquitinase BRCC36
Applications
