/ ANTIBODIES/ANTISERA / Primary Antibodies / Rabbit anti-BRCA1 Recombinant Monoclonal Antibody [BLR319M]
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Primary Antibodies  

Rabbit anti-BRCA1 Recombinant Monoclonal Antibody [BLR319M]

bethyl
Bethyl Laboratories

Catalog #

Validated
Target:

BRCA1

Reactivity:

Mouse

Applications:

IP

,

WB

Host:

Rabbit

Clonality:

Recombinant Monoclonal

Clone:

BLR319M

Format:

Whole IgG

Immunogen:

between 500 and 550

Isotype:

IgG

Purity:

Purified

100 µl (10 blots)

20 µl (2 blots)

Product Details

Specifications
Verified Reactivity

Mouse

Antigen Species

Mouse

Concentration
1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Phosphate Buffered Saline (PBS) with 0.09% Sodium Azide, BSA-Free


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Additional Product Information

BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

12189

Brca1

breast cancer 1, early onset

P48754

Breast cancer type 1 susceptibility protein homolog

Alternate Names

breast cancer associated 1;breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.