Rabbit anti-A20 Antibody Affinity Purified
Catalog #
A20
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 525 and 575
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Zinc-finger protein A20 was identified as a transcript that was rapidly induced by tumor-necrosis factor alpha (TNF-alpha). A20 is an essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Upon TNF stimulation, A20 deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P21580].
Alternate Names
A20; AISBL; OTU domain-containing protein 7C; OTUD7C; putative DNA-binding protein A20; TNF alpha-induced protein 3; TNFA1P2; tumor necrosis factor alpha-induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; zinc finger protein A20
Applications