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Mouse anti-p16INK4a Recombinant Monoclonal Antibody [BC42 ]
Bethyl Laboratories®
Catalog #
Validated
Target:
p16INK4a
Reactivity:
Human
Applications:
Flow Cyt
,ICC
,IHC
,WB
Host:
Mouse
Clonality:
Recombinant Monoclonal
Clone:
BC42
Format:
Whole IgG
Immunogen:
Human p16 INK4A
Isotype:
IgG1
Conjugate:
Unconjugated
Purity:
Purified
100 µl (50+ tests)
10 µl (5+ tests)
100 µg (BSA-Free)
Product Details
Specifications
Verified Reactivity
Human
Antigen Species
Human
Concentration
100 µg/ml
1000 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
Request Formulation Change
Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free
Request Formulation Change
Additional Product Information
p16INK4a is a negative regulator of CDK4 and CDK6 kinase activity and cell cycle progression. p16INK4a regulates the cell cycle by inhibiting cyclin/CDK complex formation and the phosphorylation of the retinoblastoma protein (pRb). The gene which encodes p16INK4a, CDKN2A, is frequently mutated or deleted in a wide variety of tumors and is known to be an important tumor suppressor gene. The CDKN2A gene also generates a distinct transcript variant and protein, p14ARF, from an alternate open reading frame (ARF).
Alternate Names
alternative reading frame;ARF;CDK4 inhibitor p16-INK4;CDK4I;CDKN2;cell cycle negative regulator beta;CMM2;cyclin-dependent kinase 4 inhibitor A;cyclin-dependent kinase inhibitor 2A;cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4);INK4;INK4A;MLM;MTS1;MTS-1;multiple tumor suppressor 1;P14;P14ARF;P16;P16INK4;p16-INK4;P16INK4A;P16-INK4A;P19;P19ARF;TP16
Applications
