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Profiling Cytokeratins in the Tumor Microenvironment Using Multiplex Immunofluorescence

This poster was originally presented at SITC 2023, the Society for Immunotherapy of Cancer Annual Meeting.

Cytokeratins have been regarded as a predictive disease marker and provide important clinical information such as tumor growth, potential metastases, and response to therapeutic agents. For clinical purposes, it’s important to capture the presence/absence of the correct keratins in a tumor microenvironment, as each has distinct diagnostic purposes (i.e., CK5/6 positivity is specific for bladder condyloma acuminatum versus basal/patchy staining in papillary noninvasive urothelial carcinoma).

This study profiled Cytokeratins (types I and II) and the overall immune profile within the tumor microenvironments of numerous cancer tissues to showcase the importance individually and collectively as tumor biomarkers. Download the poster to learn more.

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