Single-domain antibodies, also known as VHH, are a monomeric variable antibody domain. In research, therapeutic, and diagnostic applications, these single-domain antibodies have advantages over conventional antibodies. Applications of VHH include multiplex imaging, as a component of cell therapies or as a therapeutic modality themselves, and immunoassays for diagnostic and environmental monitoring assays.
In this whitepaper, you will learn:
- Features of single-domain antibodies
- The advantages (and disadvantages) of working with VHH
- Methods of VHH library construction
