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Control Line Systems for Lateral Flow AssaysArticleLateral flow tests consist of a test line and a control line. The control line provides validation of a functioning test. If the control line does not appear after running the test, that test is deemed invalid. The choice of a control line antibody will depend on which detector antibody is used in the test.
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Lateral Flow Assay Tests for Detecting Drugs of AbuseArticleDrug molecules are small and if directly striped on a membrane, they would “sink” into the sponge-like matrix of the nitrocellulose membrane. Consequently, drug molecules are conjugated to a carrier protein such as Bovine Serum Albumin (BSA) (most common), Bovine thyroglobulin (BTG), and even ovalbumin. The carrier protein part of the conjugate binds to the membrane and exposes the drug for the antibodies to “find”. In most drug tests, the drug BSA conjugate will be on the capture or test line and the antibody to that drug or its metabolites is bound to a detector particle such as gold nanoparticles or colored latex beads.
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Identifying a Novel Biomarker of Primary Sclerosing CholangitisArticlePrimary sclerosing cholangitis (PSC) is a chronic, progressive autoimmune disease, where ducts that transport bile within the liver and between the liver, gallbladder, and intestines become narrowed due to inflammation and fibrosis.1 The resulting accumulation of bile within the liver damages the tissue and ultimately leads to organ failure. Clinicians use non-specific testing including imaging, liver biopsy, and serum biochemical assays to diagnose patients with PSC.1 Moreover, patients with other liver diseases exhibit overlapping symptoms, which makes it difficult to differentiate between the diseases and correctly diagnose the patients. Clinicians require PSC-specific biomarkers to improve diagnosis, and researchers from Kyoto University have identified a potential diagnostic biomarker, anti-integrin αvβ6 autoantibodies.2
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Cell Lysate Protocols eBookEbookThis eBook is a comprehensive resource for cell lysate preparation. It covers cell lysis using RIPA and NETN, as well as specific protocols for nuclear extract preparation and immunoprecipitation.
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Drugs of Abuse Pairing GuideEbookAt Fortis Life Sciences®, we understand the importance of accurate and reliable rapid diagnostic tests for detecting drugs of abuse. That's why we are a global supplier of matched pairs of drug test reagents for use in lateral flow formats. Accelerate your development timeline by referencing this pairing guide for the selection of compatible drug test reagents.
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