ZFP91 (zinc finger protein 91 homolog) is an atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilization and activation of MAP3K14/NIK. ZFP91 thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. ZFP91 may also play an important role in cell proliferation and/or anti-apoptosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96JP5].
drug resistance-associated sequence in melanoma 8•
penta zinc finger protein•
zinc finger protein 757•
zinc finger protein 91 homolog•
zinc finger protein 91 homolog (mouse)•
zinc finger protein homologous to Zfp91 in mouse•