TFEB Antibody

Transcription factor EB (TFEB) specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. TFEB specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression; thus, TFEB plays a central role in expression of lysosomal genes. TFEB also specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P19484].
TFEB
transcription factor EB
Transcription factor EB
:  ALPHATFEB bHLHe35 class E basic helix-loop-helix protein 35 T-cell transcription factor EB TCFEB
Product
Specifications
Ordering Information
Human
WB, IP
Between 325 and 375
$339
$229
$99
Human, Mouse
WB, IP, IHC
Between 426 and 476
$339
$229
$99
Human, Mouse
WB, IP, IHC
Includes: 1 each of A303-672A and A303-673A
$472
Includes: 1 each of A303-672A and A303-673A