CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a member of the myeloid translocation gene family which interacts with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of the CBFA2T3 gene. This gene is also a putative breast tumor suppressor. [taken from NCBI Entrez Gene (Gene ID: 863)].