CHD4 is a helicase component of the nucleosome remodeling and deacetylase (NuRD) complex that functions to remodel chromatin and repress transcription. Outside of the NuRD complex, CHD4 can function as an activator of transcription in association with p300 histone acetyltransferase. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14839 and from NCBI Entrez Gene (Gene ID: 1108)].