Phosphodiesterase 8A (PDE8A) is a member of a large family of phosphodiesterases (PDEs) that regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction [taken from NCBI Entrez Gene (Gene ID: 5151)].
