BCAR1/p130CAS functions as a scaffolding protein for components of various kinase signaling pathways. It is involved in integrin signaling for cell motility as well as netrin signaling for the guidance of commissural axons. Overexpression of BCAR1/p130CAS has been shown to confer antiestrogen resistance in breast cancer cells.
BCAR1, Cas family scaffolding protein•
breast cancer anti-estrogen resistance protein 1•
Cas scaffolding protein family member 1•
Crk-associated substrate p130Cas•