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Overview of Complexome

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Proteomics is a powerful tool to study the pattern of expression of proteins under different conditions. Although traditional proteomic studies yield important information on individual proteins, they provide little information on how proteins function together to mediate biological processes.

In the early nineties, blue native electrophoresis, a technique for the large-scale analysis of protein complexes, was introduced.1  This ability to study complexomes, the network of protein complexes connected by common protein subunits, has led to an emerging field. Complexome studies can be as simple as understanding the protein make-up of viral envelope proteins or as complex as defining an entire organism’s complexome network.

 

References

1. Schaegger H, von Jagow G. (1991).  Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form.  Anal Biochem.  199(2):223–31.