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ErbB4 Antibody

ErbB4 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor; EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors homo- or heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ligands preferred by ErbB4 include neuregulins (NRG-2 and NRG-3), heparin-binding EGF-like growth factor, and betacellulin, and epiregulin. ErbB4 appears to be important to mammary gland development and lactation; however its role in breast cancer has not been unequivocally determined.
erb-b2 receptor tyrosine kinase 4
Receptor tyrosine-protein kinase erbB-4
:  ALS19 avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4 ERBB4 transcript variant I12DEL ERBB4 transcript variant I20DEL HER4 human epidermal growth factor receptor 4 p180erbB4 proto-oncogene-like protein c-ErbB-4 receptor tyrosine-protein kinase erbB-4 tyrosine kinase-type cell surface receptor HER4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 More... Less...
Ordering Information
between 1100 and 1150