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Primary Antibodies  

Rabbit anti-WNK1 Antibody

Bethyl Laboratories®
Bethyl Laboratories®

Catalog #

Validated
Citations (5)
Target:

WNK1

Reactivity:

Human

,

Mouse

Applications:

IP

,

WB

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

between 2100 and 2150

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (200 µg/ml)

10 µl (200 µg/ml)

Product Details

Specifications
Verified Reactivity

Mouse,

Human

Presumed Reactivity

Rat

Antigen Species

Human

Concentration
200 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide


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Additional Product Information

WNK1 (with no lysine 1) is a member of the WNK family of serine-threonine kinases. The WNK family of kinases has been observed to play a role in several cellular processes which include ion balance, signal transduction, survival, proliferation and organ development. WNK1 appears to be important to ion homeostasis. Mutations in WNK1 cause pseudohypoaldosteronism type II (PHA II), also called Gordon’s syndrome, an autosomal dominant disease characterized by defects in ion transport in the nephron that result in hypertension and hyperkalemia. WNK1 has been reported to regulate sodium and chloride ion transport by influencing the activity of another WNK family member, WNK4. WNKF1 has also been observed to regulate ion homeostasis independent of WNK4.

65125

WNK1

WNK lysine deficient protein kinase 1

Q9H4A3

Serine/threonine-protein kinase WNK1

Alternate Names

erythrocyte 65 kDa protein; HSAN2; HSN2; hWNK1; KDP; Kinase deficient protein; p65; PPP1R167; PRKWNK1; prostate-derived sterile 20-like kinase; Protein kinase lysine-deficient 1; protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; PSK; serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2; WNK lysine deficient protein kinase 1 isoform

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.