Rabbit anti-Sprouty 2 Antibody Affinity Purified
Catalog #
Sprouty 2
Human
IP
Rabbit
Polyclonal
Whole IgG
Between 265 and C-terminus
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Bovine
Human
2 - 8 °C
1 year from date of receipt
Sprouty 2 contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells sprouty 2 is transiently upregulated in response to fibroblast growth factor two. Sprouty 2 is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. Sprouty 2 interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. Sprouty 2 may play a role in alveoli branching during lung development as shown by a similar mouse protein [taken from NCBI Entrez Gene (Gene ID: 10253)].
Alternate Names
hSPRY2; IGAN3; protein sprouty homolog 2; Spry-2
Applications