Rabbit anti-Sirt6 Antibody Affinity Purified
Catalog #
Sirt6
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 305 and 355
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Sirtuin 6 (Sirt6) is a NAD-dependent protein deacetylase. Sirt6 displays deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Sirt6 also deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Sirt6 is important for the modulation of cellular senescence and apoptosis and the maintenance of telomeres and genomic stability [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8N6T7].
Alternate Names
NAD-dependent protein deacetylase sirtuin-6; regulatory protein SIR2 homolog 6; SIR2L6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6
Applications