Rabbit anti-SHARP Antibody
Catalog #
SHARP
Human
IP
Rabbit
Polyclonal
Whole IgG
between 1350 and 1400
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse
Human
2 - 8 °C
1 year from date of receipt
SHARP functions as a transcriptional repressor by interacting with proteins involved in deacetylation such as the NuRD (nucleosome remodeling) complex. SHARP can also repress transcription by interacting with corepressors such as SMRT/NCoR (silencing mediator for retinoid and thyroid receptors/nuclear receptor corepressor). SHARP is able to suppress transcription through the Notch/RBP-J signaling pathway by competing RBP-J binding with the intracellular domain of Notch.
Alternate Names
HIAA0929; MINT; Msx2 interacting nuclear target (MINT) homolog; msx2-interacting protein; nuclear receptor transcription cofactor; RBM15C; SHARP; SMART/HDAC1-associated repressor protein; SPEN homolog; spen homolog, transcriptional regulator
Applications