Rabbit anti-PSMD12 Antibody Affinity Purified
Catalog #
PSMD12
Human
IP
Rabbit
Polyclonal
Whole IgG
Between 406 and 456
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Bovine
Human
2 - 8 °C
1 year from date of receipt
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (PSMD12) is a subunit of the 26S proteasome, a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD12 is a non-ATPase subunit of the 19S regulator. [taken from NCBI Entrez Gene (Gene ID: 5718)].
26S proteasome non-ATPase regulatory subunit 12
Alternate Names
26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; p55; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; Rpn5; STISS
Applications