Rabbit anti-PCNA Antibody Affinity Purified
Catalog #
PCNA
Human
,Mouse
Flow Cyt
,IHC
,IP
,WB
PhenoImager™ HT
Rabbit
Polyclonal
Whole IgG
between 75 and 125
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Chicken,
Bovine,
Rat
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to PCNA immobilized on solid support.
The epitope recognized by A300-276A maps to a region between residues 75 and 125 of human proliferating cell nuclear antigen using the numbering given in SwissProt entry P12004 (GeneID 5111).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to PCNA immobilized on solid support.
The epitope recognized by A300-276A-T maps to a region between residues 75 and 125 of human proliferating cell nuclear antigen using the numbering given in SwissProt entry P12004 (GeneID 5111).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
PCNA (Proliferating Cell Nuclear Antigen) was first identified as a factor expressed in the nuclei of replicating cells. PCNA plays a role in both DNA synthesis and repair. PCNA functions as a processivity factor for DNA polymerase by acting as a DNA clamp that tethers the polymerase catalytic units to the DNA template. The structure of PCNA is that of a trimeric ring that encircles and slides along replicating DNA. PCNA interacts with and is regulated by several proteins involved in cell cycle control and check point processes.
Alternate Names
ATLD2; cyclin; DNA polymerase delta auxiliary protein; PCNA; proliferating cell nuclear antigen
Applications