Rabbit anti-PARN Antibody Affinity Purified
Catalog #
PARN
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 539 and 589
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Poly(A)-specific ribonuclease (PARN) is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. PARN prefers poly(A) as the substrate, hence, it efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. PARN is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons [taken from NCBI Entrez Gene (Gene ID: 5073)].
Alternate Names
DAN; deadenylating nuclease; deadenylation nuclease; DKCB6; PFBMFT4; poly(A)-specific ribonuclease PARN; polyadenylate-specific ribonuclease
Applications