Rabbit anti-NPM1 IHC Antibody Affinity Purified
Catalog #
NPM1
Human
,Mouse
IHC
,ihc_if
Rabbit
Polyclonal
Whole IgG
Between 250 and 294
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Horse,
Dog,
Pig,
Rabbit,
Bovine,
Monkey,
Rat
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to NPM1 immobilized on solid support.
The epitope recognized by IHC-00678 maps to a region between residue 250 and 294 of human nucleophosmin using the numbering given in entry NP_002511.1 (GeneID 4869).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to NPM1 immobilized on solid support.
The epitope recognized by IHC-00678-T maps to a region between residue 250 and 294 of human nucleophosmin using the numbering given in entry NP_002511.1 (GeneID 4869).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Nucleophosmin (NPM1) is involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF. It associates with nucleolar ribonucleoprotein structures and binds single-stranded nucleic acids. NPM1 binds ribosomes presumably to drive ribosome nuclear export. Chromosomal aberrations involving NPM1 have been identified in several types of leukemia [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P06748].
Alternate Names
B23; NPM; Nucleolar phosphoprotein B23; nucleolar protein NO38; nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); nucleophosmin/nucleoplasmin family, member 1; Numatrin; testicular tissue protein Li 128
Applications
