Rabbit anti-FOXO1a Antibody
Catalog #
FOXO1a
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 600 and C-term
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Pig,
Bovine,
Rat
Human
2 - 8 °C
1 year from date of receipt
Forkhead box protein 01A (FOXO1a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO1 is a transcription factor that integrates cell signals to mediate metabolism, the cell cycle, DNA repair, and response to cellular stress. In response to insulin, FOXO1 is phosphorylated by Akt and excluded from the nucleus and subsequently degraded. Over-expressed cytoplasmic FOXO1 interacts with TSC2 to cause its degradation and subsequent activation of the mTOR pathway; while nuclear localization inhibits the mTOR pathway.
Alternate Names
FKH1; FKHR; forkhead box protein O1; forkhead box protein O1A; Forkhead in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOXO1A
Applications