Rabbit anti-Dab2 Antibody Affinity Purified
Catalog #
Dab2
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 275 and 325
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Disabled homolog 2 (Dab2) is an adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Dab2 can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P98082].
Alternate Names
adaptor molecule disabled-2; Dab, mitogen-responsive phosphoprotein, homolog 2; differentially expressed in ovarian carcinoma 2; differentially-expressed protein 2; disabled homolog 2; disabled homolog 2, mitogen-responsive phosphoprotein; DOC2; DOC-2
Applications