Rabbit anti-CSK Antibody
Catalog #
CSK
Human
,Mouse
IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 400 and 450
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Human
2 - 8 °C
1 year from date of receipt
C-Src kinase (CSK) is a non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. CSK suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P41240].
Alternate Names
CSK, non-receptor tyrosine kinase; C-Src kinase; c-src tyrosine kinase; protein-tyrosine kinase CYL; tyrosine-protein kinase CSK
Applications