Rabbit anti-Cbl-b Antibody Affinity Purified
Catalog #
Cbl-b
Human
IHC
,IP
Rabbit
Polyclonal
Whole IgG
between 450 and 500
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Rat
Human
2 - 8 °C
1 year from date of receipt
Cbl-b is an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Cbl-b negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13191].
Alternate Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b; casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; Cbl-b; E3 ubiquitin-protein ligase CBL-B; Nbla00127; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-B; RNF56; SH3-binding protein CBL-B; signal transduction protein CBL-B
Applications