Rabbit anti-NF1 Antibody Affinity Purified
Catalog #
NF1
Human
IP
Rabbit
Polyclonal
Whole IgG
Between 1 and 50
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Rat
Human
2 - 8 °C
1 year from date of receipt
Inactivating mutations in NF1 (neurofibromin 1) result in neurofibromatosis type I (NF1) which is characterized by Schwann cell neurofibromas, café-au-lait spots, and benign lesions of the iris. At the cellular level, NF1 functions as a negative regulator of Ras activity. Loss of NF1 leads to increased levels of active Ras-GTP which is important for the formation and maintenance of Schwann cell tumors.
Alternate Names
neurofibromatosis 1; neurofibromatosis-related protein NF-1; neurofibromin; NFNS; truncated neurofibromin 1; VRNF; WSS
Applications