Rabbit anti-MIB2/Skeletrophin Antibody Affinity Purified
Catalog #
MIB2/Skeletrophin
Human
WB
Rabbit
Polyclonal
Whole IgG
Between 850 and 900
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Antibody was affinity purified using an epitope specific to MIB2/Skeletrophin immobilized on solid support.
The epitope recognized by A301-414A maps to a region between residue 925 and 975 of human mindbomb homolog 2 (Skeletrophin) using the numbering given in entry NP_543151.1 (GeneID 142678).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Antibody was affinity purified using an epitope specific to MIB2/Skeletrophin immobilized on solid support.
The epitope recognized by A301-414A-T maps to a region between residue 925 and 975 of human mindbomb homolog 2 (Skeletrophin) using the numbering given in entry NP_543151.1 (GeneID 142678).
MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.
Alternate Names
E3 ubiquitin-protein ligase MIB2; mind bomb homolog 2; mindbomb homolog 2; novel zinc finger protein; novelzin; putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; skeletrophin; zinc finger ZZ type with ankyrin repeat domain protein 1; zinc finger, ZZ type with ankyrin repeat domain 1; ZZANK1; ZZZ5
Applications