Rabbit anti-DNA Ligase 1 Antibody
Catalog #
DNA Ligase 1
Human
IHC
,IP
Rabbit
Polyclonal
Whole IgG
between 200 and 250
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
DNA ligase 1 catalyzes the joining of double-stranded DNA ends during replication, recombination, and repair. Structurally, DNA ligase 1 is toroidal and encircles nicked DNA substrates. The 9-1-1 complex, a DNA damage checkpoint complex, has been reported to associate with DNA ligase 1 and stimulate ligase activity. Mutations in DNA ligase 1 result in immunodeficiency and increased sensitivity to DNA-damaging agents.
Alternate Names
DNA ligase 1; DNA ligase I; ligase I, DNA, ATP-dependent; polydeoxyribonucleotide synthase ATP 1
Applications