RANK (receptor activator of NF-KB) is a member of the TNF-receptor superfamily. TNF-receptor family members can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. RANK and its ligand are important regulators of the interaction between T cells and dendritic cells. RANK is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells [taken from NCBI Entrez Gene (Gene ID: 8792)].