IDH1 Antibody

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. IDH1 is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production [taken from NCBI Entrez Gene (Gene ID: 3417)].
IDH1
isocitrate dehydrogenase (NADP(+)) 1, cytosolic
Isocitrate dehydrogenase [NADP] cytoplasmic
:  Cytosolic NADP-isocitrate dehydrogenase epididymis luminal protein 216 epididymis secretory protein Li 26 HEL-216 HEL-S-26 IDCD IDH IDP IDPC isocitrate dehydrogenase 1 (NADP+) isocitrate dehydrogenase 1 (NADP+), soluble NADP(+)-specific ICDH NADP-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, peroxisomal oxalosuccinate decarboxylase PICD More... Less...
Product
Specifications
Ordering Information
Human
IP
Between 1 to 50
100
$339
$99
Human, Mouse, Rat
WB, IP
Between 364 to 414
100
$339
$99
Human, Mouse, Rat
100
Includes: 1 each of A304-161A and A304-162A
$472
Includes: 1 each of A304-161A and A304-162A