BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.
BRCA1/BRCA2-containing complex, subunit 1•
breast and ovarian cancer susceptibility protein 1•
breast and ovarian cancer sususceptibility protein 1•
breast cancer 1•
breast cancer 1, early onset•
early onset breast cancer 1•
Fanconi anemia, complementation group S•
protein phosphatase 1, regulatory subunit 53•
RING finger protein 53•
truncated breast and ovarian cancer susceptibility protein 1•
truncated breast and ovarian cancer sususceptibility protein 1•
truncated breast cancer type 1 susceptibility protein•More...Less...