Cancer Research is the study of the origins and molecular biology of tumor cells and mechanisms of oncogenesis. Cancer is characterized by dysregulated biochemical signaling, growth, and death processes of cells, often caused by specific genetic mutations. Determining the phenotype, lineage, and tissue origin of tumor cells helps to determine diagnosis and prognosis. Tumor cells exhibit metabolic abnormalities and develop mechanisms of angiogenesis, metastasis, and escape from the immune response to promote their own survival, growth, and spread. The goal is to understand the mechanisms of tumorigenesis in order to prevent the development of cancer and to develop effective treatments based on the unique properties of tumor cells.
Bethyl’s cancer portfolio contains over 4,000 antibodies. These antibodies have been manufactured on-site by our scientists. Our rigorous validation process ensures that the antibody will work in the applications outlined on the datasheet. These applications include: Western blot, immunohistochemistry, immunoprecipitation, immunocytochemistry, flow cytometry, proximity ligation assay, and ChIP. A Bethyl antibody is first validated for specificity in immunoprecipitation and/or western blot and if it passes our team will validate the antibody for additional applications. Our products are backed with a 100% guarantee to work in your assay, when used in under the same conditions outlined on the product datasheet, which provides confident, reliable results.
Bethyl sells a wide variety of antibodies for cancer research. Recent publications using our antibodies for studying cancer include:
Detection of human Lamin-A (green), Matrin 3 (red), and Beta-catenin (orange) in FFPE prostate carcinoma by IHC-IF. Antibodies: Rabbit anti-Lamin-A (A303-432A), rabbit anti-Matrin 3 (IHC-00081), and rabbit anti-Beta-catenin (IHC-00584). Secondary: DyLight® 488 conjugated goat anti-rabbit (A120-201D2), DyLight® 550 conjugated goat anti-rabbit (A120-201D3), DyLight® 594 conjugated goat anti-rabbit (A120-201D4). Counterstain: DAPI (blue).
Detection of human rpL7a /SURF3 (red) in FFPE colon carcinoma by IHC-IF. Antibody: Rabbit anti-rpL7a/SURF3 (IHC-00454). Detection: DyLight® 594 conjugated goat anti-rabbit (A120-201D4). Counterstain: DAPI (blue).
Below is the entire list of targets involved in cancer research. Can’t find what you are looking for? Bethyl offers a custom antibody service.