/ ANTIBODIES/ANTISERA / Primary Antibodies / Rabbit anti-ZEB1 Recombinant Monoclonal Antibody [BLR102H]
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Primary Antibodies  

Rabbit anti-ZEB1 Recombinant Monoclonal Antibody [BLR102H]

Bethyl Laboratories®
Bethyl Laboratories®

Catalog #

Validated
Target:

ZEB1

Reactivity:

Human

,

Mouse

Applications:

Flow Cyt

,

IP

,

WB

Host:

Rabbit

Clonality:

Recombinant Monoclonal

Clone:

BLR102H

Format:

Whole IgG

Immunogen:

between 1074 and 1124 (C-term)

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Purified

100 µl (10 blots)

20 µl (2 blots)

Product Details

Specifications
Verified Reactivity

Mouse,

Human

Antigen Species

Human

Concentration
100 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide


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Additional Product Information

ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.

6935

ZEB1

zinc finger E-box binding homeobox 1

P37275

Zinc finger E-box-binding homeobox 1

Alternate Names

AREB6; BZP; delta-crystallin enhancer binding factor 1; DELTAEF1; FECD6; negative regulator of IL2; NIL2A; NIL-2-A zinc finger protein; posterior polymorphous corneal dystrophy 3; PPCD3; TCF8; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); ZFHEP; ZFHX1A; zinc finger E-box-binding homeobox 1; zinc finger homeodomain enhancer-binding protein

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.