Rabbit anti-PVR/CD155 Recombinant Monoclonal Antibody [BLR074G]
Catalog #
PVR/CD155
Human
Flow Cyt
,ICC
,IHC
,IHC-IF
,WB
PhenoImager™ HT
Rabbit
Recombinant Monoclonal
BLR074G
Whole IgG
residues 28-329 (ECD)
IgG
Unconjugated
Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
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Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free
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PVR/CD155 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It mediates NK cell adhesion and triggers NK cell effector functions. PVR/CD155 binds two different NK cell receptors: CD96 and CD226, and these interactions accumulate at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. PVR/Cd155 also promotes NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. PVR/CD155 also plays a role in mediating tumor cell invasion and migration. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P15151].
Alternate Names
CD antigen CD155; CD155; HVED; NECL5; Necl-5; nectin-like protein 5; poliovirus receptor; PVS; TAGE4
Applications
