Rabbit anti-Insulin Receptor Beta Antibody
Catalog #
Insulin Receptor Beta
Human
,Mouse
IP
,WB
Rabbit
Polyclonal
Whole IgG
Between 1332 and 1382
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Human
2 - 8 °C
1 year from date of receipt
The insulin receptor is a receptor tyrosine kinase that mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates to stimulate uptake of glucose. The insulin receptor is synthesized as a single polypeptide that is cleaved to generate an alpha and beta subunit. The subunit structure of the insulin receptor consists of a tetramer of two alpha and two beta chains linked by disulfide bonds.
Alternate Names
CD antigen CD220; CD220; HHF5; insulin receptor; IR
Applications