Rabbit anti-MCM7 Antibody
Catalog #
MCM7
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 300 and 350
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM7 is part of the core MCM complex that includes MCM4, MCM6, and MCM7. The core complex possesses DNA helicase activity. MCM7 has been shown to interact with CDK4 and p27Kip1 to regulate cell cycle progression. MCM7 has also been shown to interact with ATR-interacting protein (ATRIP)-ATR to function as a transmitter of DNA damage signals from replication forks to S-phase checkpoint machinery.
DNA replication licensing factor MCM7
Alternate Names
CDC47; CDC47 homolog; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47; MCM2; minichromosome maintenance deficient 7; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104; protein phosphatase 1, regulatory subunit 104
Applications